Based on the integrated technology of RS and GIS, combining the means of statistics and analysis, taking three TM remote sensing images in three periods(1993, 2000 and 2010 year) as the main data source, we analyzed LUCC, and selected thirsty chief driving factors of land use and cover change. Then quantitatively analyzed the correlation between different land types and different driving factors by grey correlation model in Guiyang City. The results showed as follows:(1) The area of paddy, dry land, brush and unused land reduced by 135.2, 55.4, 80.8, 98.6 km² respectively; but the area of water area, woodland and construction land increased by 49.1, 128.3, 183.4 km² respectively;(2) The comprehensive land use index was increased 301.2, 307.7, 319.0 in 1993, 2000 and 2010 respectively.(3) The orderliness and stability of land use structure system showed a trend of increase first then decrease, and the information entropy of land use structure raised from 0.76 in 1993 to 0.78 in 2001, then fell to 0.77 in 2010 in Guiyang City.(4) The main driving forces of LUCC in Guiyang City was population growth, economic development and per capita resource status.