[Objective] The characteristics of spatial distribution of PM2.5 in China and the influence factors were studied to provide scientific basis for environment monitoring. [Methods] This paper collected hourly concentrations of PM2.5 pollutant at 9:00 on February 25 th and 9:00 on March 23 th, 2014. Consequentially, the countrywide spatial distribution of PM2.5 concentration was simulated within national boundaries using bicubic B-spline method in GIS. The concentration distribution was compared with that of USA spatially atdifferent standard. [Results] The most serious polluted region is Beijing and Tianjin-centered north China, and another is Pearl River Delta. The western provinces, including Tibet, Xinjiang and Guizhou area are good-air regions with low concentration. [Conclusion] There is a stable relationship between economic growth and PM2.5 concentration.