[Objective] Studying the spatial distribution patterns of soil and water loss in the megacity is of great importance to make conservation strategies and promote constructing beautiful China in new era.[Methods] Spatial distribution patterns of soil and water loss in Wuhan City, Hubei Province, was investigated by spatial overlay analysis of land cover, vegetation coverage and ground slope according to the methods in standards for classification and gradation of soil erosion.[Results] The spatial distribution patterns of soil and water loss in Wuhan City was summarized as four circles. The core was the built-up area where the ground hardening was high and the soil and water loss was slight. The second circle was urban expansion area around the core area where the most severe soil and water loss occurred due to urban construction. The third circle was the agricultural production area in the plain around the second circle where the soil and water loss was low, but the agricultural non-point source pollution was very severe. The fourth circle was the outskirts of hilly area, mainly forest land with a small amount of slope farmland.[Conclusion] The management and maintenance of urban green space and underground drainage system should be enhanced in the core area. A great mount of urban building projects should be strictly supervised in the second circle. The construction sites should be restored to the most extend and the urban ecological landscape should be built to minimize the man-made soil and water loss. The agricultural non-point source pollution should be controlled and ecological clean watersheds should be built in the third circle. The slope farmland should be managed, ecological restoration should be improved, and the man-made soil and water loss caused by tourism development should be controlled in the fourth circle.