[Objective] The effect of large photovoltaic(PV) power station on micro-climate of desert region in Gonghe Basin was evaluated via comparing basic meteorological factors to reveal the difference of microclimate both inside and outside of the photovoltaic power station.[Methods] Based on the meteorological data measured by automatic meteorological station, the impact of large PV power stations on microclimate of desert region in Gonghe Basin was evaluated by comparing the basic meteorological elements, including air temperature, relative humidity(RH), wind speed and direction, solar radiation, and soil temperature and water content of control point and monitoring points.[Results] The RH increased by 3.93% in desert region of Gonghe Basin due to the effect of large PV power station, which was more evident in drier day and during nighttime. The prevailing wind direction shifted from northeast to east after PV power station was established, and PV power station made local wind direction more single. As for wind speed, the frequency of high wind was significantly decreased after PV power station was established, and the wind speed reduced by 53.92% in desert region of Gonghe Basin due to the effect of large PV power station. The large PV power station made mean soil temperature reduced by 17.20%, 16.75% and 16.09% at the depth of 10,20,40 cm, and the impact for shallow soil layer was more significant than that for deep soil layer. Additionally, the effect of large PV power station on soil water content in desert region of Gonghe Basin was more obvious than the ones on other factors. The mean soil water content(10 cm) was increased by 71.61% in Gonghe Basin due to the effect of large PV power station.[Conclusion] The large PV power station made the relative humidity increased, the prevailing wind direction became single, the wind speed and mean soil temperature decreased, and soil humidity increased in desert region of Gonghe Basin.