[Objective] The vulnerability of regional groundwater in Yinchuan City was examined to provide a scientific basis for the construction, planning, and protection of groundwater resources in cities.[Methods] The urban area of Yinchuan City inside the beltway was considered as the study area. According to local hydrogeological conditions, six evaluation factors, such as depth to water, recharge of precipitation, water yield properties, soil type, impact of the vadose zone, and aquifer hydraulic conductivity, were selected. The corresponding weight was calculated by the analytic hierarchy process (AHP) to establish the DRASTIC model for groundwater vulnerability assessment.[Results] ① The overall performance of groundwater vulnerability in Yinchuan City was medium-weak. The weak area was located in Xixia District, and the strong area was located in the northern part of Jinfeng District. ② The evaluation results were consistent with the pollution characteristics of NO^-₃.[Conclusion] Groundwater vulnerability assessment is an important means to protect groundwater resources. The Yuehai Lake area in the northern part of Jinfeng District can be used as the preferred area for urban expansion in the future.