[Objective] The study was conducted on the selection of organic nutrition-functional soil conditioners and the economic benefit of hybrid feeding sweet sorghum from application of it, in order to solve the bottleneck problem of grey brown desert soil that is characterized by weak water and fertilizer retention, low organic content and the successive low and unsustainable crop yield.[Methods] The ash brown desert soil in Suzhou District, Jiuquan City, Gansu Province was selected as experimental materials and field experiment was conducted.[Results] The amount of organic nutrition-functional soil conditioner was positively correlated with indices of porosity, aggregate, water holding, organic matter, available nitrogen, phosphorus and potassium, economic benefits and yield of hybrid feeding sweet sorghum, while was negatively correlated with soil bulk density and pH value. Soil bulk density and pH value decreased 4.10% and 8.27% as compared with that of conventional fertilizer. Total porosity, capillary porosity, non-capillary porosity, total water holding, capillary porosity water holding capacity and non-capillary porosity water holding capacity increased by 3.63%,3.60%,3.67%,3.63%,3.60% and 3.67%, respectively; organic matter, available nitrogen, phosphorus and potassium increased by 7.03%, 0.37%,0.33% and 0.29%; fungi, bacteria, actinomyces, sucrose, phosphatase and polyphenol oxidase increased by 121.42%, 34.69%, 20.00%, 61.79%, 45.37%, 36.00% and 63.23%, respectively. The grains per spike, grains weight, hundred-grain weight, yield, fertilizer profits and investment efficiency increased by 6.38%, 4.17%, 4.42%, 4.04%, 2 390 yuan/hm² and 0.40 yuan/yuan, respectively.[Conclusion] The grey brown soil physical and chemical properties can be effectively improved by the application of organic nutrition-functional soil conditioners in the Hexi Corridor of Gansu Province, and the water holding capacity, hybrid feeding sweet sorghum yield increased as well.