Regional ecological environment assessment provides an important foundation for drafting regional sustainable development plans and ecological environment protection measures. These are necessary because accelerating economic development in Shanxi Province is placing increasing pressure on the environment. This paper presents a feasible framework for regional ecological environment assessment based on the realities of the ecological environment of Shanxi Province. Grey comprehensive assessment is used to evaluate the quality of the regional ecological environment of Shanxi Province. Based on the framework and evaluation, some strategies for undertaking assessments are also advanced.