Based on the meteorological and natural disaster data in the Yangtze river basin during the last 60 years, we studied the influence of El Niño- Southern Oscillation( ENSO) events on the climate in the nine subbasins or regions of the Yangtze river basin including Jinshajing/Yalongjiang river, Mintuojiang river, upstream of Yangtze river.Statistical analysis of the relationships between climate factors (precipitation,temperature, natural disaster events etc.) and the ENSO event clearly showed that they had significant impacts on the precipitation and temperature in Yangtze river basin. Most El Niño events or years were warmer and drier with an increased probability of drought. Most La Nina events or years were cooler and wetter with an increased probability of flooding. T he whole basin flood disasters happened twice during the past 60 years, both of which occurred in the years transiting from El Nino events to LaNina events. El Niño had more significant and stronger influences on the climate than did La Nina. The meteorological conditions of the ENSO event during 2009 - 2010 was similar to those of 1998 during which a huge flood occurred.During 2010-2011 and the ensuing transition from the El Nino event to the LaNina event, it is more likely for the whole basin flooding to occur. For better preparedness, weather monitoring and prevention measures must be strengthened.