The desertification of the lower reaches of Tarim River and the conservation of green corridor are directly affected the socio-economic sustainable development and has great importance on the comprehensive socio-economic development of the whole Tarim River Basin.According to the recent field data combined with related research literatures,the paper studied the desertification history,current situation,its development and evolution and the relations with sustainable development in Tarim River Basin and concluded that: The desertification in Tarim River Basin"generally expanded with artially restored",which meant desertification and its control happened simultaneously but the speed of control was slower than the speed of desertification; The desertification development resulted in the existing of the desertification and oasesization at the same time with human being receding from the desertification land;The oasis was threatened severely by the desertification and the regional conservation function had been continuously weakened with the area decrease of the oasis-desert transition zone including natural forest,grassland and natural water body and led to serious problems in the socio-economic sustainable development of the region and the whole Tarim River Basin as well.Finally the main countermeasures for regional sustainable development were proposed to the solve desertification problems of this area.