The objective of this experiment is to study changes of antioxidant enzyme activity in Amorpha fruticosa L. Seedlings grown under combined drought and lead(Pb) stress. Pot experiment was carried out in a rain-proof shed to investigate the effects of drought stress(soil relative water contents were 100%, 80%, 60% and 40%), Pb stress(Pb contents were 0, 1000, 2000, 4000 and 6000 mg/kg), and the combined stress on the superoxide dismutase(SOD), peroxidase(POD) and catalase(CAT) activities in the leaves of A. fruticosa L. seedlings. Results showed that SOD and CAT activities in the leaves of A. fruticosa L. seedlings first increased and then declined, but POD activity increased with the increase of the Pb content in soil under Pb stress. With the decrease of soil relative water content under drought stress, SOD and POD activities first increased and then declined, and CAT activity first declined and then increased. SOD and POD activities significantly increased under the combined drought and Pb stress, and CAT activity increased under the combined stress when the Pb content in soil was equal to or less than 2000 mg/kg. In conclusion, A. fruticosa L. seedlings have a strong tolerance to the combined effects of drought (soil relative water content≥40%) and Pb (Pb content≤2000 mg/kg) stress.