Xinzhuangzi mining reclamation area, which located in Huainan City, was selected as the research area and seven soil enzyme activities(urease, phosphatase, invertase, protease, cellulose enzyme, hydrogen peroxide enzyme, polyphenol oxidase) were measured. The results showed significant differences among heavy metals pollution to seven soil enzyme activities. It was found that the seven soil enzyme activities were inhibited in different degrees, and the sensitivity of soil enzymes to heavy metals were not consistent. Factor analysis method was used to extract the principal component and establish evaluation index of the compound soil pollution of total enzyme activities which intended to evaluate the pollution degree of soil heavy metals in this area. The level of soil heavy metals pollution was obtained by grey clustering method. The relationship between soil enzyme activity and the heavy metal pollution in mining subsidence area were analyzed, which further proved it was feasible using the comprehensive index of soil enzyme activity to evaluate soil heavy metal pollution in special case of mining subsidence area. The overall evaluation index of soil enzyme activities, as a simple means of evaluation, will finally provide reference and theoretical basis to heavy metals pollution repairing in Xinzhuangzi reclamation area and similar coal mining area.