[Objective] The growth and nutritional quality of tomato in vegetable waste cultivation matrix were tested to provide a scientific basis for the application of vegetable waste-fermented products. [Methods] Vegetable waste was composted outdoor, and after that a series of cultivation matrices based on the fermented products was used to cultivate tomato in a greenhouse. [Results] In all treatments of vegetable waste-fermented organic matrices, the height, crown size, main stem diameter, fruit quantity and yield of tomato were all observed increased. Especially, it was obvious for the C treatment, which was made from vegetable waste, corn stover, cow dung and fermentation agents with a ratio of 100:4:2:0.25. Cultivated with that matrix, the tomato yield increased 97%, and in which, indices of nutritional quality as dry matter, organic acid, soluble sugar, vitamin C and soluble solid content increased 41.9%, 139.6%, 36.8%, 18.7% and 57.1% in comparison with the ones of the control. In all treatments, nitrite content, heavy metals and other harmful residues were less than the level of corresponding national standard. [Conclusion] Vegetable waste fermentation processed substrate can promote the growth of tomato and has its benefits to the fruit quality.