[Objective] To study the water consumption of industrial sectors of the national economy in Guizhou Province and find ways to improve the efficiency of water resources.[Methods] Based on the input-output table of Guizhou Province in 2012, this paper extended the scope of its application to the field of industrial water consumption by means of water resources input-output method, and made a quantitative analysis of the national economic water use in Guizhou Province. The traditional input-output table was combined with the consumption water phase of each department of national economy, and the water resources input-output table and the industrial water use model of Guizhou Province in 2012 was established. The direct water use coefficient, the coefficient of total water use and the coefficient of indirect water use were analyzed.[Results] The second industry department and third industry department were the main water demand departments in Guizhou Province. In addition to agriculture department, other departments also have concealment in water use to some extent. Water use multiplier of each department was high, and the potential improvement for future water use is large.[Conclusion] We should energetically develop modern agriculture and increase the water saving capacity of agriculture, and strengthen the cooperation among all sectors of the second industry, and focus on the development of green recycling industry economy. Follow up the development of "big data" in Guizhou Province and increase the proportion of high-tech industry and service industry.