[Objective] To analyze the dynamic changes of regional soil erosion intensity and its driving factors, in order to provide scientific basis for regional soil and water conservation. [Methods] Based on 3S technology, the revised universal soil loss equation (RUSLE) was used to estimate soil erosion modulus of Meihekou City, Jilin Province in 2010 and 2017. The changes of soil erosion were analyzed according to land use, slope and soil and water conservation measures. [Results] ① The average soil erosion modulus in 2000 and 2017 were 698.75 and 678.25 t/(km²·a), respectively, indicating the improvement of soil and water conservation in Meihekou City. ② The soil erosion in Meihekou City was correlated with the slope and land use. More than 95% of the soil erosion area were distributed in areas with slope <15°, and the land use was mainly cultivated land and forest land. ③ From 2010 to 2017, the mean soil erosion modulus decreased by 154.08 t/(km²·a), and the amount of soil erosion decreased by 2.65×10⁴ t in the soil and water conservation project implementation area. [Conclusion] The implementation of soil and water conservation project have improved soil and water conservation functions dramatically, but soil erosion is still existing in the treated area, and the improper transformation of land use type has aggravated regional soil erosion. Therefore, the cooperation works among different department need to be done to control the soil and water loss from the sources.