[Objective] Aiming at the problem of wind-sand disasters on the main traffic lines in desert areas, the solidification performance of local salt-containing iron tailings sand was studied to realize the preparation of mechanical sand barriers and the control of wind-sand disaster using waste.[Methods] Ordinary Portland cement and Huaxia I ionic curing agent were used to solidify salt-containing iron tailings. The durability and changes in strength of the test block were evaluated comprehensively after a dry-wet cycle, freeze-thaw cycle, and natural weathering test. The analysis emphasized the influence mechanism of pore structure change on durability.[Results] The strength of solidified specimens reached >2 MPa by mixing in 7% to 10% cement. The strength and durability of cured specimens could be improved obviously by adding 0.2‰ ionic curing agents. Analysis of the micro-pore structure showed that after the durability test, the total pore volume and the proportion of medium or large pores increased due to the migration of water vapor and salt. However, there were no connected large pores and the loss of strength was small.[Conclusion] Salt-containing iron tailings sand can be used as an engineering material, and can be solidified using cement and ionic solidifying agent to prepare mechanical sand barriers. The strength and durability tests were able to meet engineering requirements and thus have value for practical application.