[Objective] The ecosystem service value and the sensitivity of ecosystem service values to land use changes in Chengdu-Chongqing economic zone were evaluated to provide scientific references for optimizing the allocation of regional land resources, protecting the environment, and promoting sustainable development.[Methods] Chengdu-Chongqing economic zone was selected as a case study. The evolution of land use type changes and ecosystem service values were studied using ArcGIS software, based on the Landsat TM/ETM/OLI remote sensing image data of 2005, 2011, and 2017. The sensitivity of land use type change to the ecosystem service value was analyzed using the coefficient of cross-sensitivity.[Results] ① The land use type conversion in the economic zone mainly occurred in cultivated land, forest land, grassland, and construction land, and the land use dynamics of cultivated land was relatively large with a value of about 40%; ②During the research period, the ecosystem service value in the economic zone slightly fluctuated, but showed an upward trend. The forest land and cultivated land contributed to the ecosystem service value for more than 90%; ③The coefficient of cross-sensitivity between water and cultivated land increased from 2.06 in 2005 to 2.15 in 2017 which the type of land use conversion in the economic zone showed high sensitivity and increasing trend. The ecosystem service value caused by the conversion of water and construction land decreased, and the coefficient of cross-sensitivity was high. The results indicate that human activities had a significant impact on the ecosystem service value.[Conclusion] Land use policies should be formulated to optimize land use structures and to manage the development of regional ecological environment integration in the Chengdu-Chongqing economic zone.