[Objective] A coupling degree and coupling-coordination degree model between the ecological environment system and the socio-economic system in Yuanzhou District, Guyuan City, Ningxia Hui Autonomous Region was established to provide a scientific basis for the coordinated development and regulation of the region.[Methods] Based on ecological environment and socio-economic data for 2002-2016 in Yuanzhou District, an index evaluation system for the regional ecosystem of Yuanzhou District was constructed. The entropy method was used to calculate the weight of each evaluation index and the comprehensive evaluation index. By establishing the coupling degree, coupling coordination degree model, and gray prediction model, the development trend of the coupling degree and coupling coordination degree of the eco-environmental and socio-economic systems, and the type of coupling coordination, were obtained and predicted.[Results] From 2002 to 2016, the evaluation index of the social economic system in Yuanzhou District steadily increased. Due to the impact of pressure on the ecological environment, the comprehensive evaluation index of the ecosystem first had a tendency of decline, and then fluctuated. The economic system developed faster than the ecologic system. The coupling degree and coupling coordination degree were rising, and the type of coupling coordination developed from the moderately dysfunctional type of economic lag to the end, a dysfunctional type of ecological environment. Through model prediction, the coupling degree and coupling coordination between the ecological environment system and the socio-economic system was projected to gradually increase from 2017 to 2025. This type of coupling coordination would continue to evolve toward an ideal state.[Conclusion] The economic development of Yuanzhou District is faster than the construction of ecological environment, which restricts the overall coordinated development of the region. Therefore, to achieve sustainable development of the regional ecosystem in Yuanzhou District, it is necessary to strengthen construction of the ecological environment.