[Objective] The physical and chemical properties of sandy soil the growth status of Agriophyllum squarrosum with different amendments were studied, in order to provide scientific guidance for the follow-up work of desertification land management and the restoration of ecological environment.[Methods] Organic fertilizer, flaxseed meal, water-retaining material (potassium polyacrylate), humic acid and other materials were used to improve sandy soils in Northwest Margin of Kubuqi Desert. The effects of different soil amendments on the soil physicochemical properties, microorganism quantity, enzyme activities and dry matter weight of Agriophyllum squarrosum were analyzed.[Results] ① The sequence of the effect of amendments on reducing bulk density and infiltration rate of desertified soils, and increasing total soil porosity and soil field capacity were:water retaining agent (BSJ) > water and fertilizer retaining agent (BSBFJ) > adhesive (NHJ). As the soil layer depth increases within the layer of 0-30 cm, effects of the three treatments on regulating soil physical properties weakened gradually. ② The effects of amendments on reducing soil pH value and increasing soil available nitrogen and organic matter were not obvious. BSJ had the best effect on reducing soil pH value, increasing soil available nitrogen and available phosphorus, and BSBFJ was the most effective in improving soil available potassium and organic matter content. ③ Three amendments improved the dry matter weight of Agriophyllum squarrosum significantly, and the specific performance was BSBFJ > BSJ > NHJ. ④ The microorganism quantity and enzyme activity in desertified soil were greatly improved by the application of amendments. NHJ had the best effect on increasing the number of soil bacteria, actinomycetes and urease activity, while BSBFJ had the best effect on increasing the number of soil fungi, invertase activity and phosphatase activity.[Conclusion] Different types of soil amelioration materials can improve the physiochemical properties of desertified land and the growth of Agriophyllum squarrosum at vary degrees. Considering the improving effect of three soil amelioration materials, BSBFJ could be as preferred materials for improving desertification soil in the area.