[Objective] The dynamic change trend and main influencing factors of land degradation in Qinghai Province was analyzed, in order to provide a theoretical basis for ecological environment construction projects and the prevention of land degradation.[Methods] ANUSPLIN interpolation, trend analysis, Hurst index and residual analysis were employed, and the rainfall use efficiency (RUE) was used as the indicator to monitor land degradation.[Results] ① The spatial distribution of RUE and normalized difference vegetation index (NDVI) in Qinghai Province was mainly lower in the northwest and higher in the southeast. The main RUE in the west was less than 0.004, accounting for 40.77%, and NDVI in the northwest was less than 0.75, accounting for 38%. ② Land degradation of Qinghai Province in 1999-2006, 2006-2012, and 2012-2018 accounted for 5.16%, 4.25%, and 14.57%, respectively, which was mainly shifted from the middle and west to the northwest. ③ Temperature, sunshine hours, and average wind speed were significantly positively correlated with RUE, accounting for 64%, 91%, and 73%, and 24%, 61% and 32% of them passed the significance test. The negative interference of human activities on RUE accounted for 55%.[Conclusion] Land degradation in Qinghai Province in 1999-2018 decreased initially and then increased, with a weak sustainability. The influencing factors leading to the reduction of land degradation area in Qinghai Province are mainly sunshine hours, average wind speed and temperature, and human activities were also a major factor affecting land degradation.