[Objective] The spatial coupling relationship between the ecosystem service value and regional economy was analyzed to provide the basis for coordinated development of environmental protection and social economy in rocky desertification areas.[Methods] Based on the grid scale, the coupling coordination model was used to quantitatively evaluate the degree of coordinated development of ecological service value (ESV) and gross domestic product (GDP) in Panzhou City of Guizhou Province.[Results] ① The ESV "hot spot" area was mainly distributed in the minority villages and towns in the northeast, and the "cold spot" area was mainly distributed in the areas with rapid economic development and high urbanization rate. ② The spatial distribution of GDP in Panzhou City was characterized by its local high, and the high-value areas were mainly concentrated in industrial towns or economic and cultural centers, such as Shiqiao Town, the Yizi Subdistrict, and the Hanlin Subdistrict. ③ The overall distribution of ESV and GDP coupling coordination in Panzhou City was low, there was evident autocorrelation in the space, and the regions with low coupling coordination were mainly distributed in the southeast, north, and central parts of Panzhou City. ④ The type of coupling coordination between ESV and GDP in Panzhou City was mainly a severe imbalance type, accounting for 79.95% of the total area of the region.[Conclusion] Considering the low degree of spatial coupling of ESV and GDP in Panzhou City, balancing environmental protection and economic development would help to improve the coordination.