[Objective] The habitat quality of the high-efficiency eco-economic zone in Yellow River delta (YRD) was studied in order to reveal the impact of human activities on the ecological environment of the region and provide references for the ecological protection and development of the YRD.[Methods] Based on the land use data of the YRD in 2000, 2010 and 2018, the InVEST model, land use degree index and bivariate space autocorrelation model were used to analyze the spatial-temporal evolution characteristics of habitat quality and its correlation with land use change.[Results] ① Cultivated land and wetland were the main land use types of YRD. Construction land and wetland increased continuously. The main change direction was from cultivated land, grassland and unused land to wetland and construction land. ② The habitat quality of the YRD was above medium level on the whole. Medium, medium-high and high grades areas accounted for more than 82%, and the habitat quality kept improving. However, the habitat quality showed a "mid-course reduction and two-end growth" trend, in which the habitat quality of medium-low, medium and medium-high decreased while the habitat quality of high and low increased continuously. ③ The habitat quality of the YRD showed a significant spatial heterogeneity. The habitat quality of coastal and along the Yellow River areas dominated by wetland was higher, while that of construction land and cultivated land distribution area was lower. ④ There was a significant negative correlation between land use degree and habitat quality, and the correlation was increasing.[Conclusion] The connectivity protection should be strengthened for the high-grade habitat in YRD, and green space construction shuold be strengthened for the built-up areas with serious habitat degradation to improve the habitat quality.