[Objective] The suitability of ecological-living-industrial spaces in the Southwestern Guangxi-Beibu Gulf region was evaluated in order to provide a reference for the complex transitional geographic space to achieve the ecological-living-industrial and land-sea coordination, and to provide theory for scientifically delineating the spatial layout of the land.[Methods] The spatial suitability evaluation index system of ecological-living-industrial in Southwestern Guangxi-Beibu Gulf region was constructed. The coefficient of variation method was used to determine the index weights, and the evaluation results were analyzed by ArcGIS technology.[Results] ① The industrial and ecological suitability in the transitional and complex geographic spatial distribution characteristics of the karst and Beibu Gulf region in Southwest Guangxi Zhuang Autonomous Region showed "mutual-differences". From karst to coastal areas, the production space suitability increased gradually, but the ecological space suitability decreased gradually. ② The suitability of living space in karst area was generally weaker than that of Beibu Gulf region. ③ In the suitability evaluation of composite space, the proportion of compound space dominated by ecological space was the highest (accounting for nearly 1/2), followed by production space sand the living space. ④ The proportion of marine ecological-living-industrial suitability in descending order was production-ecology-production and living, and there was a conflict between coastal marine ecological space and terrestrial production and living space.[Conclusion] The suitability of ecology and production space is mainly restricted by natural conditions, and the suitability of living space is mainly affected by administrative location. There is a game between ecological protection and social and economic development in coastal zone.