[Purpose] The water safety in Gansu Province was evaluated, in order to provide scientific basis for local departments to formulate corresponding regional water safety measures.[Methods] By constructing DPSIR evaluation index system, water safety of Gansu Province in 2000, 2005, 2010, 2015 and 2018 was evaluated by using the method of entropy value and single index quantification, multi-index synthesis and multi-criteria synthesis.[Results] The water safety and health of Gansu Province had increased from unsafe in 2000 to less unsafe in 2018, showing an upward trend on the whole but to a lesser extent, it was still below the basic safety line. As for the criterion level, the driving force rose slowly and the pressure was still high, while the response level was limited, which was the main limiting factor for the development of water safety and health to a better state. Although the state and influence were in a less safe state, they increased steadily year by year, which was an important driving force for the development of water safety and health to a higher level.[Conclusion] The current situation of water safety in Gansu Province is not optimistic and unsafe. It is necessary to change the current situation of water safety from three aspects:water resources, ecological environment and social economy.