[Objective] The resilience and main obstacle factors of the social-ecological system in Zhangjiajie City, a typical tourist city, in Hu’nan Province were analyzed to provide a theoretical basis for the sustainable development of Zhangjiajie City. [Methods] An evaluation system of the social-ecological system resilience of Zhangjiajie City was constructed based on three subsystems (social, economic, and ecological) and two aspects (vulnerability and response capacity). The characteristics of resilience changes and the main obstacle factors from 2010 to 2019 were analyzed using the set-pair analysis method and an obstacle degree model. [Results] ① The social-ecological system vulnerability index of Zhangjiajie City increased from 0.457 0 to 0.553 5, response capacity index increased from 0.229 5 to 0.769 4, and resilience index increased from 0.378 8 to 0.627 6. ② There were eight main obstacle factors affecting the resilience of the entire system, such as the proportion of employment in the tertiary industry. The average obstacle degree of the subsystems was greatest for the social subsystem, followed by the economic subsystem and then the ecological subsystem. [Conclusion] ① Although the resilience index of the social-ecological system of Zhangjiajie City was increasing, it currently remains in the middle resilience stage and needs further improvement. ② The obstacle degree of single factor and subsystems changes constantly, so it is necessary to monitor the trends of changes in order to adjust the countermeasures in a timely manner.