[Objective] The freeze-thaw adaptability of frost-resistant artificial soil and its application effects in slope vegetation restoration were studied by use of indoor and outdoor tests of various soil physical and chemical indexes in order to provide scientific support and a basis for the application of slope vegetation restoration in an alpine region. [Methods] The physical and chemical properties of soil after 60 freeze-thaw cycles were measured by indoor tests, and representative indexes were selected by principal component analysis for outdoor tests. The practical application effect of artificial soil in Xizang alpine region for four yesrs was monitored by outdoor sampling. Natural soil was used as a control sample during both indoor and outdoor tests. [Results] Compared with natural soil, the freeze-resistant artificial soil had significantly improved its freeze-resistant stability and fertility (p<0.05), which was reflected in that the relative dynamic elastic modulus, ＞0.25 mm water stable large aggregate content, average weight diameter, aggregation degree, organic matter, ammonium nitrogen, nitrate nitrogen, available phosphorus, and available potassium content in frost-resistant artificial soil were significantly greater than that in the natural soil before and after freeze-thaw (p＜0.05). While the mass loss rate and structural failure rate in frost-resistant artificial soil were significantly decreased. Principal component analysis showed that the relative dynamic elastic modulus, structural failure rate, pH value, and organic matter content in indoor tests were highly correlated with principal component factors. Therefore, these four indicators were selected for outdoor sampling and monitoring of vegetation restoration in the field. The monitoring results showed that the structure failure rate was lower, and the relative dynamic elastic modulus, and organic matter content of frost-resistant artificial soil were greater than for the natural soil at different time periods in four yesrs. In terms of vegetation restoration effect, the vegetation coverage, species diversity, aboveground biomass, and underground biomass for frost-resistant artificial soil were greater than for natural soil. [Conclusion] Frost-resistant artificial soil has better vegetation restoration effect when applied in alpine region, especially its freeze-resistant durability, aggregate stability and fertility are outstanding, which are better than natural soil, so it is more suitable for slope vegetation restoration application.