[Objective] The effects of soil physicochemical properties and enzyme activities on slopes under different restoration measures after disturbance from alpine wetland highway projects were analyzed in order to provide a theoretical reference for the screening of alpine wetland vegetation restoration models, soil erosion control, and improvement of the ecological environment. [Methods] We compared three slope treatments (natural succession, spraying grass planting, and turf cover) against the original undisturbed vegetation (the control). Soil physicochemical indexes and soil enzyme activities were measured, and their interrelationships and influencing factors were analyzed. [Results] ① All three restoration measures resulted in a significant increase (p＜0.05) in soil pH value and total potassium compared with the control. These restoration measures also resulted in a significant decrease (p＜0.05) in soil organic matter, total nitrogen, fine root biomass, and available potassium under the natural succession treatment, with minimum values of 15.16 (±0.15), 0.75 (±0.01), 0.60 (±0.27), and 65.00 (±4.5), respectively. The proportion of clay particles in the soil was significantly lower (p＜0.05) under the spraying grass planting and turf cover treatments. The richness indices of the spraying grass planting and natural succession treatments were significantly lower (p＜0.05) than observed for the control, with a minimum value of 1.29 (±0.02) under the natural succession treatment. Soil pH value, organic matter, total nitrogen, available potassium, fine root biomass, and richness index were higher for the two types of restoration measures (turf cover and spraying grass planting) than for natural selection. The richness indices for the two restoration measures were higher than for natural succession. ② Compared with natural succession, spraying grass planting and turf cover could better recover sucrase, urease, alkaline phosphatase, and catalase activity,, and even catalase activity could be recovered close to that of the control. The activities of the four enzymes were the smallest under natural succession conditions, which were 12.65±10.87,0.24±0.03,0.23±0.05 and 1.73±0.48, respectively. 0.48). ③ The correlations between the activities of the four enzymes and the physical and chemical properties of the soil were significant. Urease activity was the most sensitive to the physical and chemical properties of the soil, and was able to evaluate the soil quality of the slopes of the plateau wetland very well. [Conclusion] Compared with natural succession, spraying grass planting and turf cover can effectively improve soil physical and chemical properties and increase soil enzyme activity. Soil enzyme activity can be used as a sensitive indicator for evaluating the soil quality of slopes in plateau wetlands.