[Objective] The level of coordination between green development and rural revitalisation in the Sichuan-Guizhou region and influencing factors were analysed in order to provide a scientific basis for promoting green development and rural revitalisation in the western regions of China, thus facilitating the coordinated development of both aspects. [Methods] This study focused on data from 30 cities and prefectures in the Sichuan-Guizhou region for the period 2011—2020. A comprehensive indicator system for green development and rural revitalisation was developed. Coupling coordination and Tobit models were employed to analyse the coupling coordination relationships between green development and rural revitalisation and influencing factors. Heterogeneity were conducted based on regional characteristics. [Results] ① The green development index in the Sichuan-Guizhou Province fluctuated slightly because of different policy influences; differences between regions were significant. The rural revitalisation index significantly increased after implementation of the rural revitalisation strategy, and differences between regions were relatively small. ② The coupling coordination level between green development and rural revitalisation in the Sichuan-Guizhou region showed an upward trend over time. ③ Considering the impact of economic, policy, and geographical factors on the level of coordination between green development and rural revitalisation in the region, all influencing factors, except for elevation, were significant and positive. ④ Educational development, scientific and technological innovation, traffic conditions, environmental regulations, terrain slope, and elevation had significant heterogeneity in different regions. [Conclusion] The Sichuan-Guizhou region should encourage and support economic development, take note of government influence, engage in industrial structure adjustment and upgrading, continuously improve levels of education and technological innovation, enhance transportation conditions, and address environmental regulations. Tailored approaches should be implemented to enhance coordination between green development and rural revitalisation based on local conditions.