[Objective] The spatial patterns and driving factors of the frequency of land-use dynamic transfer changes in Guizhou Province were analysed in order provide theoretical references for land survey work and related policies in the region. [Methods] Based on the land-use data of Guizhou Province from 2000 to 2020, the spatial and temporal distribution characteristics of the frequency of land-use change in Guizhou Province were analysed using land-use change frequency statistics, kernel density analysis, and spatial autocorrelation, and the influencing factors were studied using geographic probes. [Results] ① The area of land changed in the land use change frequency in Guizhou Province from 2000 to 2020 was only 2%, but the inputs of capital and manpower were relatively high; as a result, there was a relationship between the two inputs and discordance. ② The land that changed in land-use change frequency in Guizhou Province from 2000 to 2020 had significant spatial heterogeneity in spatial distribution. ③ The kernel density of changed land in Guizhou Province from 2000 to 2020 showed the distribution characteristic of “higher in the west and lower in the east”, with the distribution density of one land change being the largest and the distribution density of three land changes being the smallest. ④ In 2000 to 2020, both changed and unchanged land in Guizhou Province showed significant spatial agglomeration characteristics, with changed hotspots in areas such as, Hezhang, and Dafang and unchanged hotspots in areas such as Xianning and Congjiang area. ⑤ The results of the interaction detection of the driving factors of land-use change frequency in Guizhou Province from 2000 to 2020 showed that the interaction of slope and slope direction had the strongest explanatory power for the spatial variation in land-use change frequency in Guizhou Province. [Conclusion] An obvious spatial heterogeneity exists in the distribution of land-use change frequency in Guizhou Province. A mechanism to regulate the frequency of land-use change in Guizhou Province should be established to realise the effective use of social resources and reduce the financial burden on society.