[Objective] This study aims to reveal the spatiotemporal dynamics and driving mechanisms of the eco-environment in the Liaohe River Basin and establish an ecological management zoning framework to support regional ecological protection and sustainable development. [Methods] Based on the Remote Sensing Ecological Index (RSEI) from 2000 to 2022, this study analyzed the spatiotemporal dynamics in eco-environment quality, identified key driving factors, and constructed a multidimensional ecological zoning framework by integrating RSEI spatial distribution patterns, trends, and driving factors. [Results] (1) The eco-environment quality in the Liaohe River Basin has improved year by year, with a spatial pattern of "poor in the middle, excellent in the east and west." (2) Precipitation is the primary driving factor of RSEI spatial variation, followed by land use, temperature, elevation, and slope. (3) Based on the zoning results, the entire basin can be divided into ecological core protection areas, ecological optimization areas, ecological monitoring areas, ecological restoration areas, and ecological key management areas. Ecological core protection areas are concentrated in the eastern basin, while ecological key management areas are located in the central basin. [Conclusion] From 2000 to 2022, the eco-environment quality of the Liaohe River Basin improved continuously, with precipitation and land use being major influencing factors. The multidimensional ecological management zoning method proposed in this study provides a scientific basis for differentiated ecological management.