[Objective] The spatiotemporal evolution patterns and driving mechanisms of ecosystem service value in Hexi Corridor were investigated in order to provide a scientific basis for ecological restoration and sustainable development in arid regions. [Methods] Based on land use data, regional grain yield and price data, and other data from 2000 to 2023, the ecosystem service value coefficient table for Hexi Corridor was revised. Subsequently, the spatiotemporal evolution characteristics of ecosystem service value in this region were systematically analyzed. The GeoDetector and geographically weighted regression models were employed to further analyze the influence of various factors on regional ecosystem service value. [Results]① During the study period, land use types in the region were predominantly unused land and grassland, with particularly significant increases in the area of construction land and water bodies.② The total ecosystem service value in the region showed an overall increasing trend with fluctuations during the study period. Among ecosystem service types, the value of water body ecosystem services showed the most pronounced increase, with regulating and supporting services dominating. The spatial distribution pattern of ecosystem service value exhibited a ‘high in the south and low in the north, high in the east and low in the west'.③ GeoDetector results indicated that socioeconomic factors provided the strongest explanatory power, followed by natural factors. Geographically weighted regression results revealed a positive correlation between the comprehensive land use degree index and ecosystem service value. Annual precipitation showed a predominantly positive correlation with ecosystem service value, with locally negative correlations. Total population exhibited a predominantly negative correlation with ecosystem service value, with locally positive correlations. NDVI and elevation demonstrated an overall pattern shifting from positive correlations in the southeast to negative correlations in the northwest. [Conclusion] Significant spatial differences in ecosystem service value exist across the three major ecological functional zones of the Hexi Corridor(mountainous, oasis, and desert regions). In the future, to ensure regional ecological security and sustainable development in the northern desert zone, people should enhance water conservation and ecological barrier functions preferably in the southern Qilian Mountains; focus on the coordinating of human activities with ecological land use in the central oasis zone; and give priority to promoting natural restoration.