Based on the geographic information system and remote sensing, the spatial distribution of karst rock-desertification is studied, and the 1∶100000 map of rock-desertification is made. The methods of bivariate correlation and principal component are used to pick up the information included in driving factors. The relations between rock-desertification and each factor are discussed, and then the system of influential factors indexes are built. As a result, the percentage of forest cover, area of karst regions, drainage networks density, arable land, area of cultivated land, average altitude, cultivation index, grassland and ≥25° surface slope are proved to be the key factors to the rock-desertification. The rock-desertification dynamic index (I R) is also established and the significant value of each factor is calculated. The most important factor of karst rock-desertification is irrational human activity. Its comparison with the GIS-RS derived data shows that I R can reflect the potential capacity of the rock-desertification and also the dynamic process is studied to reveal the dominant factors in karst regions. All these studies may be of great help for the mitigation of the rock-desertification.