In karst region,rock desertification is related to stratum and lithology,incising of river,soil erosion,gradient and mankind action etc.The problem on how lithology affects rock desertification in karst region are analyzed.In the meantime,analysis of desert spatial distributing and grade is based on desert correlation data in Qingzhen city by GIS technique and data computing system.So it can be obtained that rock desertification area is the biggest and degree is the highest in limestone area,but it is reverse in marregion.Therefore,it is thouht that grade and distribution of rock desertification are related to the stratum and lithology in Karst region.