The Maowusu Desert and the Tengeli Desert are important deserts in the North China. The Maowusu Desert lies to the eastof the Helan mountain and the other lies to the westof it. From 1986 to 2000,affected by climatic change and increasingly intensif ying force of anthropic activity,land cover land use of the margin regions of two desert,which falls into Shannxi Province,Gansu Province and Ningxia Hui Autonomous Region,had changed evidently. Attributing to different dry-humid terrain and other factors,land-cover land-use change of two desert marginal regions displayed different trait each other. The study used method of analysis landscape structure to describe the difference of the wo marginal regions,and with it,to expose different mode of ecological environ-mentresponding to variety of climatic and anthropic activity,which happened in two marginal regions being partof ecotone in the semi-arid or arid of the North China.