Water resou rces are a kind of strategic resources and have the vital significance to the regional ecological environment security and sustainable development.This paper utilizes the GIS secondary development technologies to set u p an information system for regional water resource management, which includes data management subsystem, model base subsystem, and water resource management subsystem.Evaluation model of regional water resource stress based on the artificial neural network belongs to the model base sub- system and it quantitatively reflectst he coordinated degree between regional water resource conditions and regional population, economy, and environment by the water resource stress index.The model is then vali- dated by the case studies for the whole Shaanxi Province and cities in the province.The result proves that it has theoretical f easibilit y and realistic significance.Its application and the development foreground are discussed finally.