Increased exotic plant invasion has a great effect on ecology, especially on highway side-slope. In order to find out the influence degree of exotic plant invasion on local ecosystem, statistics are made for vege-tation on highway side-slope in He′nan Province by field investigation methods. 58 plant species are investi-gated totally. 4 kinds of exotic plant invasion are identified, of which some invades the region heavily, such as Conyza canadensis. However, some artificial plants are facing extinction due to inadaptable field environ-ment, such as Cosmos bipinnata. For above problems, control suggestions are proposed, such as taking arti-ficial control, shortening the time of vegetation restoration on side-slope, selecting ornamental plants critical-ly, and enhancing the research on exotic plant invasion.