On the basis of defining the meaning of the health of land use system, the evaluation index system for the health of land use system was constructed based on the press-state-response(PSR) model, then an empirical analysis was conducted in China by entropy method and grey prediction model. The results showed that: (1) The health level of land use system had been gradually improved from 1999 to 2008 in China, with the comprehensive index increasing from 0.3935 to 0.5331. The health of land use system generally experienced two stages, i.e., unhealthy and critical state. (2) The pressure index showed a downward trend, while status index and response index showed a rising trend. (3) The growth rate of fixed asset investment, per capita cultivated land, land reclamation rate, extent of soil erosion and per capita GDP were proved to be key constraints for further improvement of the health of land use system. (4) The health level of land use system show a steady upward trend from 2009 to 2015, and the health degree of land use system reaches the sub-health state in 2014. Finally, some measures was proposed for the further improvement of the health of land use system.