The research on ecological safety, especially that of regional land use/cover is a hot issue, which is of great significance to the protection of regional ecological environment and the sustainable development. This paper, using TM images in 1980, 2000, 2010 as the data source, developed a comprehensive index method to evaluate the ecological security of land use, analyzed the temporal and spatial variation of the ecological security in Songnen Plain during 1980 to 2010, and predicted the ecological security pattern in the next 40 years. The results showed that: (1) The risk of ecological security in land use increased from the northeast to the southwest. (2) The lower risk area proportion is the largest, accounting for more than 50%. From 1980 to 2000, the other risk areas were reduced and transformed to lower risk area. This indicated that ecological environment pressure has been decreased. However, from 2000 to 2010, The conversion of low and lower risk areas to higher risk areas is obvious. (3) The prediction showed that during the period from 2020 to 2050, the area of moderate risk, high risk, and higher risk levels will increase gradually, and the ecological environment will deteriorate seriously.