Nandagang wetland in Hebei Province was took as the research area. In order to obtain the area data of Nandagang coastal wetland, four remote-sensing images of 1989, 1999, 2009, 2012 and two classified topographic maps of 1969 and 1979 as auxiliary information. Based on the dynamic change information of Nandagang wetland which extracted by using the RS and GIS technical, the natural factors and human factors influencing the evolution of Nandagang wetland were analyzed. By using the synthesis matrix analytic method and the intensity of human disturbance model, wetland degradation degree was evaluated quantitatively, and the main factors causing the degradation of wetlands were discussed. The result shows that:(1) Affected by natural and human factors, the natural wetland of Nandagang decreased by 37.22%, the artificial wetland increased by 98.13% in 43 years. Among all the artificial wetland, the marine park, reservoirs and ponds and the saltern have growth most obviously.(2) The wetland is almost in the natural state in 1969 and the comprehensive index factor of degradation is low, while the comprehensive index factor increased significantly since 1979.(3) The intensity of human disturbance is faint in 1969, the intensity of human interference on Nandagang costal wetland is strong in 1969-1979. The wetland disturbance degree was not obvious in 1979-2012, and wetland continues to degenerate.