Collecting the statistical data of remote sensing and socio-economy in Three Gorges Reservoir area in 2007 and 2010, the full cover 20 km×20 km grid were adopted to generat the space plots. Based on the geo-statistical method, the spatial distribution of population carrying capacity of cropland in Chongqing section of the Three Gorges Reservoir area were simulated and analyzed. The results indicated that, the carrying capacity of cropland's profit and loss value in Three Gorges Reservoir area changed from 2007 to 2010. The carrying capacity of cropland overloaded 4.6376 million people in 2007. And in 2010, the carrying capacity of cropland had a potential space for 565700 people. The carrying capacity of cropland in Three Gorges Reservoir area had an obvious trend effect. In east-west direction, the trend effect was 1-order, and was multi-order in the north-south direction; The carrying capacity of cropland had strong spatial correlation. The spatial distribution of carrying capacity of cropland was in banding shape in the Three Gorges Reservoir area, and it reduced gradually from southwest to northeast. From 2007 to 2010, the spatial distribution of carrying capacity of cropland changed, and the capacity increased in the southwest part of nine districts, while reduced obviously in Jiangjin and Changshou Districts.