[Objective] To explore the response of land surface humidity to the regional climate change in Hexi Corridor.[Methods] The daily meteorological data from 14 stations during the period from 1960 to 2011 were used to calculate the referential evapotranspiration and humid index for each site based on the Penman-Monteith model. The Sen's slope and Mann-Kendall trend test were used to analyze the temporal and spatial variation of humidity and its influential factors in the study area.[Results] The humid index of Hexi Corridor was around 0.00~0.56, and the humid index increased during the past 52 years. The humidity conditions showed a spatial variation due to the differences in climate and terrain. The seasonal humid index showed an increasing trend as a whole, with the greatest increases in winter, while smallest changes in summer.[Conclusion] Hexi Corridor is subject to arid climate, while the humid index increased slightly in the past 52 years due to the increase in precipitation and decrease in wind speed.