[Objective] To determine the fertilization index system and provide the precision fertilization formula for mulched potato system in Shandan County of Zhangye City, Gansu Province.[Methods] Fourteen field experiments were conducted in mulched potato system in Shandan County of Zhangye City, Gansu Province from 2007 to 2010. The relationship between the soil available nutrient content and the corresponding crop yield was established.[Results] The soils in Shandan County was classified into 5 different categories such as the lowest, lower, medium, higher and the highest according to the content of alkali-ydrolyzable nitrogen, available phosphorus and available potassium. Fertilizer application rate was recommended for each soil categories, such as >225.7, 193.3~225.7, 117.2~193.3, 161.0~177.2 and <161.0 kg/hm² for nitrogen, >164.3, 146.5~164.3, 137.6~146.5, 128.6~137.6 and <128.6 kg/hm² for phosphorus, >166.8, 149.7~166.8, 141.1~149.7, 132.5~141.1 and <132.5 kg/hm² for potash. The new technologies can improve potato yield by 9.8%, save fertilizer by 67.5 kg/hm², reduce cost by 506.3 yuan/hm², and increase economic profit by 3 286.5 yuan/hm².[Conclusion] The technologies of soil testing and fertilization formula can improve potato yield and increase economic profit generally.