[Objective] A study of soil and water loss was conducted on three typical geomorphic styles(karst plateau mountain, basin and canyon) in Guizhou Province in order to reveal the effects of landform factors(gradient, slope length, slope shape, slope position, slope exposure and micro topography) on the loss of regional soil and water, and to provide a theoretical basis for integrated prevention of soil and water loss in karst area. [Methods] Using the flow monitoring in standard runoff fields and erosion baseline method, many years' data of soil and water loss of 3 types of geomorphic style were obtained. Data were analyzed by Excel and SPSS software. [Results] Slope gradient was the leading direct trend factor that can influence the slope loss of soil and water. Soil erosion increased with the increase of slope degree and 25 degrees was the critical gradient. Slope length of karst slope was not an obvious affecting factor on soil and water loss. Slope shape exerted indirect impaction on soil and water loss by slope position and slope direction. The influence rank of slope position on soil and water loss was that down slope > middle slope > upper slope. Soil erosion occurred on sunny slope was greater than that on the shady slope. It was very obvious that micro topography can obviously affect soil and water loss, erosion occurred easily on protuberant section, and deposit was often observed in slope hollows. [Conclusion] Soil and water loss in karst area was a result of many factors. Terrain factors influenced each other and they controlled together the occurrence and trend of soil and water loss on karst slope.