[Objective] Daily runoff and sediment process in Taoxi watershed in the Southeast of China were simulated to provide a support for soil and water conservation plan.[Methods] The annualized agricultural non-point source pollution model(AnnAGNPS) was adopted to simulate the daily runoff and sediment yield. Differential sensitivity analysis(DSA) methods were carried out to evaluate the sensitivity of input parameters.[Results] (1) Curve number, field capacity and Maning's-reach were the sensitive parameters for runoff simulation. K-factor, surface residue cover, root-mass, remained residue cover after cultivation, random roughness, Maning's-reach and disturbed area were the major sensitive parameters for sediment load estimation.(2) In the calibration and validation processes of both runoff and sediment simulation, R² and Ens had values above 0.66 for daily runoff and were above 0.62 for daily sediment load modeling.[Conclusion] AnnAGNPS model can simulate well for daily runoff and sediment process in the study area.