[Objective] The impact factors of urban water security in Guizhou Province were studied to provide basis for policy-making of local government. [Methods] A water security system model for Guizhou Province, China was established using system dynamics(SD) method. In the model, data of water security system from 2005 to 2025 were used and four scenarios(Guiyang model, Zunyi model, Bijie model and concerted development model) were analyzed. [Results] The major driving factors of the water security system in Guizhou Province included the agricultural irrigation water quota, soil and water losses area, ratio up to the standard of water quality and the investment of environmental protection. The concerted development model is the best solution for water security system by 2025 in Guizhou Province for the four scenarios. [Conclusion] In terms of water resource, water environment and water disaster, the concerted development model was proved to be a profitable solution both in economy and environment.