[Objective] We aimed to study the changes of land use/cover and its influencing factors in Weigan-Kuqa river delta oasis, in order to provide the basis for the oasis ecosystem health maintenance.[Methods] This article selected Weigan-Kuqa river delta oasis as the study area. Landsat TM/ETM⁺ image data in the year of 1989, 2001 and 2013 was collected. By dynamic model and land transfer matrix analysis, we analyzed the characteristics of land use/cover change and its driving factors including climatic, social and economic factors.[Results] (1) During the past 25 years, there was no change in the land use/cover type in the Weigan-Kuqa river delta oasis, but the proportion of each type changed greatly. (2) The area of cultivated land increased by 114.52%, which was mainly converted from grassland and other land. The area of saline land increased by 66.11%. In contrast, the area of woodland, grassland, water and other land use types decreased.[Conclusion] In recent 25 years, the land use/cover in Weigan-Kuqa river delta oasis changed greatly. The variation of woodland, grassland, water and saline land was driven by natural factors, while the variation of cultivated land and other land use types was driven by population and economic factors.