[Objective] The land-use change during 2005—2014 was monitored in order to provide the scientific data for the policy making and ecological environment protection in Tianjun County of Qinghai Province. [Methods] Based on the IRS-P6 satellite image of 2005 and 2014, the technical methods and operation process of remote sensing monitoring for the land-use change in the key region of Tianjun county was studied. [Results] In 2009, the dominated land-use type was grass, which was slightly less than that in 2005. The area of mud flat and unused land was slightly increased. The area of the construction land was still smallest because the area proportion was only as low as 0.29%, although its annual growth rate was increasing rapidly. Regarding to the annual changes, the water area decreased by almost 66.2% in the past ten years and the annual decreasing rate was 6.62%. The area of construction land increased fast and reached 59.98% in the past 10 years and the annual increasing rate was 6.00%. [Conclusion] Local economy has developed fast during 2005—2014, and the urbanization level has been improved greatly. However, regarding to the total area proportion of construction land, the change of land-use in the monitoring area is little and the annual change rate is only 0.13%.