[Objective] The paper aims to understand the dynamic change of ecological environment vulnerability in Liangshan region from 2000 to 2010, and to provide references for regional ecological environment management and protection.[Methods] Using the technologies of RS and GIS and taking ecological sensitivity-resilience-pressure(SRP) model, we selected 16 evaluation indicators to conduct quantitative analysis on the spatio-temporal change of ecological environment vulnerability in Liangshan region during in 2000—2010.[Results] The ecological environment vulnerability of Liangshan region exhibited an overall trend of higher in south and lower in north; In terms of the single dynamic degree, the potential vulnerability was highest while moderate vulnerability was lowest, and the region's overall change speed was close to moderate level based on the comprehensive dynamic analysis, but the comprehensive index of ecological vulnerability indicated that the whole ecological environment vulnerability of the region exhibited a slow deteriorating trend.[Conclusion] The spatial distribution of ecological environment vulnerability in Liangshan region is obvious, and the ecological environment control efforts need to be strengthen.