[Objective] The main stream of synclinal basin core in Zigui County of Hubei Province was selected as an case study area, and the slope stability evaluation under transient rainfall infiltration was carried out to provided scientific support for disaster prevention and mitigation projects of government departments, and to provide scientific basis for landslide hazard prediction and management.[Methods] Based on TRIGRS infinite slope stability calculation model coupled with groundwater dynamics, the data processing procedure and parameter selection methods of the slope stability evaluation tool was introduced in detail.[Results] Slope instability mainly located in the region with loose soil having medium thick or thicker layer, and medium slope, especially in the region having soil thickness of 7 to 10 m, and terrain slope ranged 20° to 30°, where were high incidence areas of slope instability.[Conclusion] Under the synergic effects of soil layer thickness and topography, short-duration but heavy rainfall can lead to the increase of pore-water pressure, where slope sliding happen easily, which was determined as landslide high risk area. The slope stability evaluation results were in good agreement with the actual distribution of landslides, and it can reflect the spatial distribution of rainfall-induced landslides to some extent.