[Objective] Based on the present popularising plantation of rice under drip irrigation with plastic film mulching, the integrate water and fertilizer technologies in cold region were studied, and an optimized water and fertilize scheme of high yield and high efficiency was put forward in order to provide technical reference and theoretical foundation of matching water and fertilizer management for widespread use of upland rice under drip irrigation with plastic film mulching.[Methods] Using Longjing 31 and Kongyu 131 as materials, the effects of water and fertilizer coupling on yield components and yield of rice under drip irrigation with plastic film mulching in cold region were studied using randomized block experiment design.[Results] Panicles per square meter of the two varieties were both increased in a treatment. Drip-watering volumetric low level of the treatment was 80% of the saturated moisture content, and applied fertilizers at tillering and panicle-growing stages were 87 kg/hm² and 15 kg/hm², respectively. Grain numbers per panicle of the two varieties in all treatments were not significantly different in drip irrigation with plastic mulching. The biomasses, harvest indexes and economic yields of the two varieties were both observed higher in the treatment using 80% of the saturated moisture content as drip-watering volumetric low level than that in the treatment using 60% as the low level. Economic yields of the two varieties were both the lowest in the treatment using 60% of the saturated moisture content as low watering level and simultaneously applying 70 kg/hm² and 12 kg/hm² fertilizers at tillering and panicle-growing stages. For Kongyu 131 variety, the appropriate water and fertilizer coupling pattern in regime of drip irrigation with plastic mulching was as follows:watering low level at 80% of the saturated moisture content, 87 kg/hm² and 15 kg/hm² fertilizers at tillering and panicle-growing stages. For Longjing 31 variety, it was:watering with low level at 80% of the saturated moisture content, 70 kg/hm² and 12 kg/hm² fertilizers at the two stages, respectively.[Conclusion] The responses of the two rice varieties to different treatments of water and fertilizer coupling were different. Water and fertilizer coupling in regime of drip irrigation with plastic film mulching had important effect on the rice yield in cold region.