[Objective] On the basis of national geographical conditions monitoring data in Yibin City of Sichuan Province in 2010 and 2015, this paper analyzed land use dynamic and its landscape response by method of GIS and landscape ecology, aimed to provide reference for local land use and exploitation, and ecological security.[Methods] GIS and landscape methods were used.[Results] The results showed that the cultivated land and forest land composed the background of land use type in the studied area, and other landscapes distributed fragmentally among them. The land use pattern of this area had been changed conspicuously from 2010 to 2015, and landscape types converted into each other frequently. The shape complexity, fragmentation and aggregation were remarkable diverse for each landscape components in the studied area. From change pattern for each landscape component, it had been found that the stabilities of buildings, roads and water had been enhanced, while that of other components had been weakened. Because of urban construction and activity of agricultural production, the whole landscape had been distributed evenly in the direction toward the development of landscape, and fragmentation had been enhanced. Influenced by vertical zonality, the higher elevation was, the lower fragmentation of landscape; the simpler the shape of patches and the greater the dominance of landscape were.[Conclusion] In the future, the ecological protection and urban planning in this area should be combined with land use pattern and regional advantages, be governed and constructed by various ways for different regions. It should be reduced for the human activity in the ecological functional area, strengthen the conservation of water conservation function and the construction of the ecological barrier in the upper reaches of the Yangtze River. In the key development zone along the rivers, it should be regulated for the development and utilization of urban space, so as to promote the sustainable development of this area.